• Drug Like Properties Concepts Structure Design And Methods

Drug Like Properties Concepts Structure Design And Methods

Drug Like Properties Concepts Structure Design And Methods

( from 245 reviews )
  • Author
    Li Di Edward H Kerns
  • Publisher
    Elsevier
  • Publication date
    26 July 2010

UNLIMITED BOOKS, ALL IN ONE PLACE. FREE TO TRY 30 DAYS. SUBSCRIBE TO READ OR DOWNLOAD EBOOK FOR FREE. START YOUR FREE MONTH NOW!

eBook includes PDF, ePub, Mobi, Tuebl and Kindle version
FREE registration for 1 month TRIAL Account. DOWNLOAD as many books as you like (Personal use). CANCEL the membership at ANY TIME if not satisfied. Join Over 550.000 Happy Readers.

All secure, we guaranted 100% privacy and your information is safe
Recent Activity
Loading...

Loading ...

Loading...

Book Detail

  • Book Title

    Drug Like Properties Concepts Structure Design And Methods

  • Author

    Li Di Edward H Kerns

  • Date Published

    26 July 2010

  • Publisher

    Elsevier

  • Pages

    552 pages

  • ISBN

    9780080557618

Book Description

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process.

The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties.

* Serves as an essential working handbook aimed at scientists and students in medicinal chemistry
* Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies
* Discusses improvements in pharmacokinetics from a practical chemist's standpoint

© euro-book.net 2021

1108 Members Online